If you've never seen Phoebe in "Gremlins" then you're missing out on a treat, and you should go and watch it as soon as you're done reading this list. That role alone made her a household name, and her success was only amplified by the successful follow up in the 1990s. For a whole generation, though, we'll forever be enchanted and touched by her performance - and incredible chemistry - with Rik Mayall in "Drop Dead Fred" in 1991.
Phoebe could have gone on to achieve whatever she wanted in acting but retired from the profession in 1994 following her marriage to actor Kevin Kline, choosing to focus on raising her children. She returned as a one off in 2001's "The Anniversary Party" as a favor to her friend Jennifer Jason Leigh, but these days she focuses on her New York based boutique store "Blue Tree", which opened in 2003.