Obviously, all planes climb high and move fast. Air Force One has significantly more power than your average plane, though. When it's flat out, it moves at 600 miles per hour. That's pretty close to supersonic speed.
It's also comfortable flying at 45,000 feet, which ensures it has clear skies to fly through. The majority of passenger planes never go higher than 30,000 feet. Air Force One isn't going to collide with anything up there - it's almost in a world of its own.