While making 'Scary Movie 5' together, Lindsay Lohan refused to kiss Charlie Sheen because she was 'concerned about his lifestyle choices.' Hello pot, meet kettle. As with Janet Jackson years earlier, it would seem that Lohan had misapprehensions about how certain diseases can or cannot be transmitted between people. In fairness to Lohan, she told the producers she didn't want to do any kissing scenes with Sheen when she accepted the role, so they left the scenes in the script despite knowing she wouldn't do them. That's on them, not her.
If you've seen the movie (and if so, you have our sympathies), you might recall thinking you saw Sheen and Lohan kiss. You didn't. That was a body double for Lohan who performed the scene for her. Although it would have been easy for Sheen to be offended by all of this, apparently, he wasn't. He's very much aware of his reputation.