Many of the memes which we now know and love started out life as stock photos. There's a certain insincerity about the way they're posed which makes them rich sources of mockery. Those who came across this picture online thought the girl in it looked like a wide-eyed college freshman, who came from a sheltered upbringing, and therefore would become easy prey for the more worldly-wise boys she'd meet at university.
Kerin Portillo, the subject of the meme, may indeed once have been a sheltered freshman, but if she was, she grew up very quickly. The Colombian quickly realized that the meme was being shared as much for her good looks as it was anything else, and increased her charges for modeling services as she started to become better known. As we can see in the picture on the right, she's enjoying the fame.