If you've never given 'BoJack Horseman' a chance, I get it. It's a cartoon about a horseman with the last name Horseman. It's not exactly crying for your adult attention. The thing is, this is one of the best shows on TV right now, and it's certainly the most consistently good Netflix show. Despite being a cartoon, and a cartoon about animals at that, the show is extremely poignant. It's able to tackle serious issues by using the animal characters to make those ideas more palatable.
As far as jumping right into this show, you may want to catch up on old seasons first, but that's just because they are so good. Give season one a couple of episodes to warm up, but that might be my recommendation for most shows. By season two this show is firing on all cylinders.