'A Million Little Things' is already being described as a 'This is Us' clone, which doesn't bode well for the future of the genre, if you can call it that. Much like all of the 'Lost' clones, the 'This is Us' clones may even be good, but it will be difficult to escape the shadow of such a behemoth series. This show does have a great cast going for it though, which may give it a chance at success.
The plot is where this show runs into trouble. The plot follows a group of friends who reevaluate their lives following the suicide of a friend. It's dark territory, which can make for great dramatic fodder, but we'll see if they can nail such a delicate topic. If you're looking for a recommendation for this one, signs are leaning towards no.