Thompson struggled to find her feet during the 1990s. She was deemed too old to play the parts she'd become known for playing but also didn't look old enough to take on more mature roles. Caught between the two, she turned her attention away from making movies to find out what opportunities awaited her on television. The answer was 'Caroline in the City,' a 'Friends' spin-off in which Thompson played the lead role. It ran for four years from 1995 to 1999.
Her most recent major role was a six-year stint in 'Switched at Birth' from 2011 to 2017, although she continues to do episodic work. When she's not in front of a camera, she's at home with her director husband Howard Deutch, who she met back in the 80s while filming 'Some Kind of Wonderful.'