Casting a new Spider Man is always a difficult process for a director. The character is supposed to be much younger than most conventional superheroes, and also has to be wiry and nimble. Tom Holland seemed to appear from nowhere at the perfect time for the 'Avengers' series; he'll still only be 22 even when the final film has been released. He'll continue on in the role though, having already wrapped filming on 'Spider Man: Far from Home.'
Perhaps it's a consequence of Holland being so young, but almost nothing has changed about his appearance when he's been turned from male to female. Despite that, it's easy to identify one of the pictures as a man, and the other as a woman. We can't quite put our finger on what the telltale sign is, but it's definitely there. We can say with certainty that Holland would have no difficulty passing himself off as a woman if a role ever called for it!