Frank Zappa didn't live his life the way anybody else wanted to. He was a wildly eccentric character who experimented with a lot of drugs, and was heavy into psychedelia. His pursuit of the unusual extended into his naming strategy for his children, as his daughter Moon Unit can attest to. Zappa considered himself to be a satirist and a social commentator as well as a musician, and stayed committed to his artistic visions all the way through to his death.
Zappa suffered from an aggressive form of prostate cancer which ultimately made performing as a musician too painful for him, but he still gave interviews up until his final days. This still image is actually from a video recording of an interview which he gave in late 1993, not long before he died in December of that year. As you can see from the image, he was already in hospital by the time the interview took place.